Fig. 3: C9-miR zebrafish exhibited attenuated miniature endplate currents (mEPCs) at NMJs. | Communications Biology

Fig. 3: C9-miR zebrafish exhibited attenuated miniature endplate currents (mEPCs) at NMJs.

From: Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish

Fig. 3

a Recordings of mEPCs, which result from spontaneous release of a quantum, were recorded in 6 dpf control and C9-miR fish (n = 6). b Representative mEPCs. Animals with reduced C9orf72 (C9-miR) displayed mEPCs with reduced frequency (c) (n = 6–7; ***p < 0.0001; Student’s t test) and amplitude (d) (n = 7; **p < 0.001; Student’s t test). Rise time (e) (n = 7; p = 0.3947; Student’s t test) and decay time (f) constant kinetics of mEPC (n = 7; p = 0.8385; Student’s t test) were not found to be significantly different between controls and C9-miR. Data are presented as mean ± SEM. n represents the number of fish.

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