Fig. 2: Steady state proteome differs in young wild-type and APP/PS1 mouse hippocampus. | Communications Biology

Fig. 2: Steady state proteome differs in young wild-type and APP/PS1 mouse hippocampus.

From: Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model

Fig. 2

a Schematic and timeline of BONLAC labelling protocol. b Fold change vs. intensity distribution plot of all newly made proteins detected in wild-type (WT) vs. 3–5-month-old APP/PS1 hippocampus (light grey), with proteins that were detected in majority of samples (>3 out of five biologically independent samples; grey) and dysregulated candidate proteins identified by C-score screen (upregulated ≥ 20% in red, downregulated ≤ 20% in blue). c Doughnut plot showing the proportion of detected proteins that were downregulated (fold change < 0.8, blue), upregulated (fold change > 1.2, red) or unchanged in the majority of 3–5-month-old APP/PS1 mice compared to WT littermates. d String diagram depicting enriched gene ontology groups. e Top functional clusters in 3–5-month-old APP/PS1 mice compared to WT using DAVID. Red = upregulated proteins. Blue = downregulated proteins.

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