Fig. 3: Analysis of altered de novo proteome highlights impaired proteostasis in aged APP/PS1 mice. | Communications Biology

Fig. 3: Analysis of altered de novo proteome highlights impaired proteostasis in aged APP/PS1 mice.

From: Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model

Fig. 3

a Fold change vs. intensity distribution plot showing all proteins detected in 12+-month-old APP/PS1 mouse hippocampal slices vs. wild-type (WT) littermates using BONLAC (light grey). Dark grey overlay depicts proteins that were consistently detected in the majority of samples (>4 out of 7 biologically independent samples), and candidate proteins identified by C-score screen as upregulated (fold change ≥ 1.2) shown in red, while downregulated proteins (≤0.8) are labelled blue. b Doughnut plot indicating the majority of proteins detected in 12+-month-old mice are not altered in APP/PS1 mice (742; 86.8% of proteins detected). 23 proteins are downregulated compared to WT mice (2.7% of proteins show a fold change > 0.8, blue) and 90 proteins are upregulated in APP/PS1 mice (10.6% of proteins show a fold change < 1.2, red). c String diagram showing enriched gene ontology networks. d DAVID-identified functional clusters in 12+-month-old APP/PS1 mice. Red = upregulated proteins. Blue = downregulated proteins.

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