Fig. 5: The biological pathways affected by dysregulated hippocampal protein synthesis vary with age in APP/PS1 mice. | Communications Biology

Fig. 5: The biological pathways affected by dysregulated hippocampal protein synthesis vary with age in APP/PS1 mice.

From: Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model

Fig. 5

Hierarchical clustering heatmap reveals similarities and divergence in the mean-normalized log protein fold change of the 791 proteins detected in both young (3–5 months old) and aged (12+ months old) APP/PS1 mice relative to wild-type (WT) littermates. GO analysis evidenced six major clusters being modified, which are: (1) protein processing in the endoplasmic reticulum (FDR 3.2E-04); (2) synapse (FDR 5.6E-07); (3) synaptic vesicle cycle (FDR 2.77E-06), membrane trafficking (FDR 6.24E-11) and synapse (FDR 4.82E-29); (4) axo-dendritic transport (FDR 4.86E-08) and glycolysis/gluconeogenesis (2.56E-05); (5) myelin sheath (5.17E-18) and Alzheimer’s disease (8.16E-07); and (6) mitochondrial part (FDR 2.54E-08) and electron transfer activity (FDR 4.02E-05). FDR generated by StringDB algorithms. Red = upregulated proteins. Blue = downregulated proteins. White = unchanged protein expression.

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