Fig. 6: Steady state proteome is predominantly distinct throughout aging. | Communications Biology

Fig. 6: Steady state proteome is predominantly distinct throughout aging.

From: Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model

Fig. 6

a Minimal overlap is observed between proteins that are dysregulated (as detected by C-score rank algorithm) in the hippocampi of 3–5-month-old (young) vs. 12+-month-old (aged) APP/PS1 mice. b Hierarchical clustering of log fold changes reveals the majority of proteins, which are dysregulated in both young and aged APP/PS1 mice compared to WT littermates do not show the same trend. Red = upregulated proteins. Blue = downregulated proteins. White = unchanged protein expression. c String diagram revealing an enrichment of proteins in the GO network ‘Cytosolic ribosome’ in APP/PS1 throughout the aging process. White arrows = direction of regulation in young mice. Teal arrows = direction of regulation in aged mice.

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