Fig. 8: Age-dependent expression of SARS-CoV-2 entry site transcripts in the MOED, CV, and GG. | Communications Biology

Fig. 8: Age-dependent expression of SARS-CoV-2 entry site transcripts in the MOED, CV, and GG.

From: Age-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms

Fig. 8

Assessment of the expression of Ace2 and Tmprss2 transcripts in chemosensory systems by RT-PCR (left part of panels) and qRT-PCR (right part of panels) at the indicated age in months (M). An age-dependent increase in Ace2 (a–c) and in Tmprss2 (d–f) is observed in the MOED (a, d), CV (b, e), and GG (c, f). Gapdh is used as a reporter gene and H2O as a negative control of transcript expression. Samples for gene expression profiles are obtained from 5 to 6 heterozygous OMP-GFP mice of indicated age. Data are expressed as an RNA-fold change relatively to the 0.5 M and represented as mean ± SEM with aligned dot plots for n = 4 individual sample values. For comparisons between conditions, two-tailed Student’s t-tests or Mann–Whitney tests are used, *p < 0.05, **p < 0.01, ***p < 0.001, ns for nonsignificant. Ladder of 100 base pairs (bp).

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