Fig. 3: Associations between hair lead (Pb) levels and mean diffusivity (MD) (N = 919).
From: Lead exposure is associated with functional and microstructural changes in the healthy human brain
a Regions with significant positive correlations between hair lead levels are overlaid on a single-subject T1 image from SPM8 (the image file with the name of “single_subje_T1”). Results were obtained using a threshold-free cluster enhancement (TFCE) of p < 0.025 based on 5000 permutations. Results were corrected at the whole-brain level. The color bar represents the TFCE score. It reflects both voxel’s height and the sum of the spatially contiguous voxels supporting it; therefore, it reflects both the strength and extent of effects. Significant correlations were found in white-matter areas adjacent to the right fusiform gyrus. b Scatter plot of the associations between hair lead levels and mean MD in the cluster in (a). c Regions with significant negative correlations between hair lead levels and MD are overlaid on a single-subject T1 image from SPM8 (the image file with the name of “single_subje_T1”). Results were obtained using a TFCE of p < 0.025 based on 5000 permutations. Results were corrected at the whole-brain level. The color bar represents the TFCE score. It reflects both voxel’s height and the sum of the spatially contiguous voxels supporting it; therefore, it reflects both the strength and extent of effects. Significant correlations were found in extensive gray and white-matter areas of the left hemisphere. d Scatter plot of the associations between hair lead levels and mean MD in the largest cluster in (c).
