Fig. 1: Sequence similarity network (SSN) of the MIP superfamily.
From: AQPX-cluster aquaporins and aquaglyceroporins are asymmetrically distributed in trypanosomes
a SSN is composed of 16,170 nodes (squares), which represent proteins sharing >85% sequence identity, connected by edges with an average pairwise alignment score of at least 35. Edge length is a measure of the relative dissimilarity of each pair of sequences. Nodes are colored by the size of each cluster (numbered 1–10). Nodes found in clusters with <20 nodes were arbitrarily considered to uncluster. Names indicate clusters containing already characterized proteins. b MIPs distribution among clusters and taxonomic composition of each cluster according to the three-domain system of classification (Archaea, Bacteria, and Eukarya).
