Table 3 Combined de novo LGDs and coding CNVs in simplex and multiplex autism.

From: Rates of contributory de novo mutation in high and low-risk autism families

Group

Events number

Expected events number

delta

p-value

AD

SSC affected

389

205.7

183.3

5 × 10−11

9.80% (6.91–12.46)

AGRE affected

150

126.2

23.8

0.062

2.15% (−0.64–5.03)

  1. The table shows our joined analysis of the de novo LGDs and the coding de novo CNVs that allowed us to avoid the assumptions of independence between the two classes. The “events number” column shows to total number of de novo LGDs and de novo coding CNVs larger than 4KB in the two groups of affected children. The “expected events number” was computed by using the appropriate normalization factor for the two classes: number of de novo synonymous variants for de novo LGDs and the number of children for the coding de novo CNVs. Table 1’s legend describes the “delta”, “p-value”, and “AD” columns.
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