Fig. 5: Linear modulation of brain responses by performance speed.
From: A role for GABA in the modulation of striatal and hippocampal systems under stress
To show the modulation effect across blocks of practice, the β-estimate was multiplied with the modulation regressor vector and data were then averaged across time points within each block of practice. It is noteworthy that due to missing fMRI data, one extra control participant was excluded. a Effect of stress on HC dynamical activation ([30 −36 −2mm], 69 voxels, Control vs. SCR, T = 3.05, pSVC = 0.036). The averaged BOLD fitted response shows that right HC activation decreased more across blocks of practice in the stress group as compared to controls. b Across groups, bilateral STR responses increased with performance speed improvement. For illustrative purposes, the graph depicts the groups separately and the averaged BOLD fitted response is based on the right dorsal putamen ([22 16 2 mm]) but other clusters exhibited similar results (see Supplementary Table 5 for all clusters). Error bars indicate SEM in both panels. For display purposes, activation maps are overlaid on a T1-weighted template image with a threshold of p < 0.005 uncorrected.
