Table 1 HB Patient Clinical Information. Staging, histology, diagnostic, and outcome data for HB patients evaluated in this study (follow-up is time from sample collection).
Patient # | Sample source | PRETEXT stage | Histology | Invasion on path | Metastasis | Patient qutcomes | Follow-up (Days) | PDX model |
|---|---|---|---|---|---|---|---|---|
17 | Liver | N/A | HB—epithelial (fetal, embryonal), macrotrabecular, poorly differentiated small cell with anaplastic features | Negative margins, vascular invasion | None | Deceased | 139 | X |
18 | Liver | N/A | HB—epithelial (fetal & embryonal), mesenchymal without teratoid features, HCC-like; 50% viable | Negative margins, lymphovascular invasion | None | Alive without disease | 970 | X |
20 | Liver | IV | HCC—Grade 3-4 | Positive margin, vascular invasion, negative LN (0/1) | None | Deceased | 171 | |
21 | Liver | IV—P,E,F | HB—epithelial (embryonal), pleomorphic, HCC like; 80% viable | Focal positive margins, lymphovascular invasion, negative LN (0/3) | None | Alive without disease | 946 | X |
22 | Liver | III—F,C | HB—small foci of treated disease, no subtypes specified | Focal positive margin, LN negative (0/1) | None | Alive without disease | 773 | |
23 | Liver | III—P,V,C | HB—Mild pleomorphism, otherwise treated disease; 25% viable | Negative margins | None | Alive without disease | 835 | X |
24 | Liver | IV—V,P,E,F,C,M | HB—HCC-like, small cell undifferentiated, mesenchymal osteoid; 5–15% viable | Negative margins, focal tumor rupture, vascular invasion, LN negative (0/1) | Bilateral lungs | Alive with lung recurrence | 742 | |
25 | Liver | IV—V,P,F,M | HB—epithelial (fetal), osteoid; <10% viable | Focally positive margins with nonviable tumor, vascular invasion, LN negative (0/3) | Bilateral lungs | Alive without disease | 805 | |
26 | Liver | IV—F,C | HB—epithelial (embryonal, fetal), blastemal component; 15% viable | Negative margins, lymphovascular invasion, LN negative (0/1) | None | Alive without disease | 790 | |
27 | Liver | III—C,M | HB—epithelial (fetal, embryonal), osteoid; 45% viable | Negative margins, lymphovascular invasion, LN negative (0/1) | Bilateral lungs | Alive without disease | 742 | |
28 | Liver | III—M | HB—osteoid, epithelial (fetal), undifferentiated small cell; 15% viable | Margin positive, lymphovascular invasion, LN negative (0/2) | Bilateral lungs | Alive without disease | 762 | |
30 | Liver | IV—M | HB—epithelial (fetal, embryonal), transitional, small cell undifferentiated, HCC like, pleomorphic; 80% viable | Negative margins, lymphovascular invasion | Bilateral lungs | Alive with liver recurrence | 670 | X |
31 | Liver | II—M | HB—epithelial (fetal, embryonal), mesenchymal, with blastema; 50% viable | Margin positive, lymphovascular invasion, LN negative (0/2) | Bilateral lungs | Alive with metastatic disease | 664 | |
38 | Liver | IV—P,V,F,C | HB—epithelial, mesenchymal with teratoid features. 50% viable | Negative margins, vascular invasion, LN negative (0/6) | None | Alive without disease | 557 | |
53 | Liver | IV—P,V | HB—epithelial (embryonal, pleomorphic) and HCC-like; focal mesenchymal with osteoid. 50% viable | Negative margins, vascular invasion, LN negative (0/5) | Bilateral lungs | Alive without disease | 269 |
