Table 1 Mutations present in P. aeruginosa strains passaged in increasing concentrations of octenidine followed by 10 passages on TSA in the absence of octenidine.
From: Pseudomonas aeruginosa adapts to octenidine via a combination of efflux and membrane remodelling
Parental strain | SmvR (186aa) | PssA (271aa) | PgsA (186aa) | Other | OCT MIC fold increase over parental strain |
|---|---|---|---|---|---|
NCTC 13437 | K51Ra | D240E | SNP in smvA/R promoter | 256 | |
372261 LCV | R3C | V222G | 32 | ||
372261 SCV | 123a | ParS A168V | 32 | ||
CAS2 | Δ43–52 | D240G | PmrB S284N, HasR V667I | 128 | |
CAS3 | A143P | V222G | 64 | ||
CAS4 | Δ82–109 | T58M | PmrB T132P | 32 | |
GH12 | Δ106–109 | V222G | 64 | ||
PAO1 | Δ106–109 | PA3328 P51H (probable FAD-dependent monooxygenase) | 2 |
