Table 1 Kinetics of sub-ms clamshell motions of GluA2-LBD-G446C-T685W in presence of partial and full agonists.

From: Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains

 

Apo

Quisqualate

Glu

Willardiine

5-Iodo-willardine

Kainate

a1

0.17 ± 0.01

—

—

—

—

—

τ1 (µs)

113 ± 14

—

—

—

—

—

a2

0.25 ± 0.03

0.06 ± 0.01

—

—

0.05 ± 0.01

—

τ2 (µs)

6 ± 2

4 ± 1

—

—

7 ± 1

—

a3

0.48 ± 0.07

0.22 ± 0.02

0.20 ± 0.03

0.17 ± 0.01

0.22 ± 0.01

0.15 ± 0.03

τ3 (ns)

320 ± 140

180 ± 50

300 ± 50

290 ± 100

116 ± 35

190 ± 40

  1. Amplitudes (an) and corresponding time constants (τn) are the mean of three measurements (n = 3 ± s.d.). (—) no kinetics observed.
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