Table 1 Extent of puncture hole thrombus fill.

From: Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates

Sample

Puncture hole diameter (μm)

Unfilled central cavity diameter (μm)

P values (horizontal)

Volume fill (%)

1 min post-puncture

 Thrombus 1

223

65

 

70

 Thrombus 2

172

113

 

40

 Thrombus 3

116

74

 

36

 No anti-P-selectin Abs

229

212

 

18

 Mean ± SD, n = 4

192 ± 62 μm

114 ± 68 μm

P = 0.06

26 ± 14%

5 min post-puncture

 Thrombus 5

167

100

 

40%

 Thrombus 6

166

53

 

68

 Thrombus 7

189

74

 

61

 Thrombus 8

198

67

 

66

 No anti-P-selectin Abs

169

50

 

70

 Mean ± SD, n = 5

178 ± 14 μm

69 ± 20 μm

P = 0.006

61 ± 12%

 P values, (vertical)

P = 0.68

P = 0.28

 

P = 0.18

  1. Dimensions and volume fill were determined from 3D renderings of the individual thrombi done in Amira software. The unfilled central cavity is continuous with the vault volume present in the intravascular thrombi crown found 5 min post-puncture. Cavity dimensions decrease with time. SD standard deviation. P values were calculated using the Student t-test for either paired data or unpaired data with unequal variance. Calculated P values point to a significant variance in central cavity diameter versus puncture hole diameter, i.e., a numerical indicator of a progressive, localized accumulation of platelets inward from the exposed puncture hole adventitia.
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