Fig. 2: Oculomotor delayed response task and behavioral effects of CNO administration on session completion and error frequency.

a Time sequence of the one-direction reward (1DR) saccade task. A memory cue was briefly presented in either the left or the right direction. Within a block of trials, a large reward (0.4 ml of water) was consistently associated with one direction, whereas a small reward (0.1 ml) was associated with the opposite direction. The association between reward size and direction was pseudo-randomly changed in each block without any cue. b Proportion of complete and incomplete sessions before (right) and after (left) double virus transduction. Upper: Monkey W. Lower: Monkey S. Yellowish colors indicate complete sessions, and greyish colors indicate incomplete sessions. *P < 0.05, **P < 0.01, ***P < 0.001, n.s. non-significant (common to all figures). c Success rate on the first 160 trials before CNO/VEH administration (Pre) and on the last 160 trials after CNO/VEH administration (Post), separately calculated for large- and small-reward trials for Monkey W (upper) and Monkey S (lower). Each dot indicates the success rate per session for each condition. VEH condition: bluish bars; CNO condition: Yellowish bars. Error bars: standard error of the mean. d Average length of consecutive errors during Post before (right panels) and after (left panels) double virus transduction. Each dot indicates the average length of consecutive errors per session. CNO clozapine N-oxide, VEH vehicle.