Fig. 4: Progression of atherosclerosis is retarded in Pcyox1−/−/Apoe−/− mice.
From: Prenylcysteine oxidase 1, an emerging player in atherosclerosis
Representative images of H&E staining of the aortic root from Pcyox1+/+/Apoe−/− and Pcyox1−/−/Apoe−/− mice fed a HFD for 4 (a) or 8 (b) weeks. c Quantification of atherosclerotic lesion size. Data are presented as circle plot, with each circle representing an individual mouse and bars showing the mean value ± SEM. d Characterization of lesion phenotype according to the atherosclerosis stages: IX intimal xanthoma, PIT pathological intimal thickening, FCA fibrous cap atheroma. Statistical significance was calculated by Fisher exact test. e, f Representative images and quantification of atherosclerotic areas in the whole aorta by en face analysis. The bright white material is unstained atherosclerotic lesions. Statistical significance calculated by Student’s t test. Data are presented as circle plot, with each circle representing an individual mouse and bars showing the mean value ± SEM.
