Table 1 Body weight, plasma lipids levels, and other biochemical parameters in Pcyox1+/+/Apoe−/− and Pcyox1−/−/Apoe−/− fed a HFD for 8 weeks.
From: Prenylcysteine oxidase 1, an emerging player in atherosclerosis
Measurement | Pcyox1+/+/Apoe−/− | Pcyox1−/−/Apoe−/− | p value |
|---|---|---|---|
Body weight, g | 33.6 ± 4.3 (21) | 29.0 ± 2.6 (21) | <0.001 |
Total cholesterol, mg/dL | 933 ± 120 (13) | 687 ± 191 (18) | <0.001 |
Non-esterified cholesterol, mg/dL | 406 ± 34 (12) | 307 ± 84 (18) | <0.001 |
Cholesterol esters, mg/dL | 503 ± 69 (12) | 376 ± 112 (17) | <0.01 |
Triglycerides, mg/dL | 218 ± 59 (12) | 121 ± 55 (17) | <0.001 |
Phospholipids, mg/dL | 626 ± 77 (13) | 481 ± 118 (18) | <0.001 |
Non-esterified fatty acids, mmol/L | 0.256 ± 0.03 (8) | 0.195 ± 0.10 (12) | n.s. |
Plasma apoB, μg/mL | 182 ± 14 (14) | 177 ± 28 (18) | n.s. |
ALT activity, mU/mL | 10.9 ± 2.4 (8) | 9.3 ± 1.8 (11) | n.s. |
AST activity, mU/mL | 14.1 ± 8.6 (8) | 13.4 ± 8.2 (12) | n.s. |
Glucose, mg/dL | 255 ± 36 (13) | 197 ± 44 (18) | <0.001 |
PAI-1, ng/mL | 0.371 ± 0.087 (5) | 0.194 ± 0.094 (8) | <0.01 |
