Fig. 2: Clustering and regulation of oncogenic signaling pathways and kinase phosphoproteins.
From: Pan-cancer proteogenomic investigations identify post-transcriptional kinase targets
a Hierarchical clustering of phosphoproteins in oncogenic signaling pathways across ten cancer cohorts. The color intensity indicates the pathway activity scores (“Methods”). b Fractions of tumors showing alteration of protein/phosphoproteins in the signaling pathway compared to other protein/phosphoproteins (p-value < 0.05). The color intensity represents the percentage in a given pathway activity. c Volcano plots of differentially phosphorylated kinases in the oncogenic signaling pathways. Significant markers are labeled and the chosen phosphosites representing the kinase phosphoprotein levels are in the Supplementary Data.
