Fig. 6: UCP1 is the primary driver of thermogenesis in brite adipocytes.

a, d Heat flow, b, e accumulated heat, and c, f accumulated heat expressed as a percentage increase over basal for the first hour of the experiment for isolated mature inguinal from WT mice (n = 4, solid line and solid bar) and UCP1 KO mice (n = 6, dashed line and empty bar) on the same genetic background treated with either vehicle (black) or 1 µM CL316243 (red). Statistics was calculated using paired t-test on the underlying raw data. P value for Vehicle vs. CL316243 is 0.0114 (*) in WT and 0.0172 (*) in UCP1 KO cells. The curves show mean value ± SEM. The bars presented in this figure represent the mean value whereas the symbols represent each individual adipocyte isolation.