Fig. 7: Expression of let-7b-5p in the cerebral cortex in all animal models.
From: Neuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy
a Images of NeuN positive neuronal cells (green) with let-7b-5p expression (red) and coexpression is shown (yellow) in the cerebral cortex of control (arrows indicate coexpression), hypoxic-ischaemic in the ipsilateral and contralateral region and intrauterine inflammation model. b Graph showing the statistical significance between the neonatal encephalopathy models vs. control groups (n = 4–6 per group). c–d Relative expression (2-ΔΔCt) of let-7b-5p (c) and let-7b-3p (d) in peripheral blood in the form of DBS from the rat animal models. Error bars represent mean with SEM. ns not significant, * and *** denote significant p < 0.05 and p < 0.001, respectively using ANOVA with Dunnett’s multiple comparisons test. Scale bar = 25 μm. CTL control, HI hypoxic-ischaemic, ipsi ispsilateral side, contra contralateral side, IUI intrauterine inflammation.
