Fig. 8: BDNFpro restores memory retention in p75-flox mice.
a Schematic diagram depicting the behavioral paradigm used for ORT. Mice were subjected to familiarization (sample phase) with two identical objects (circles). A test phase in which one familiar object (circle) is substituted with a novel one was performed after 10 min (square) and 24 h (triangle). b Schematic diagram depicting the experimental paradigm. p75-flox mice and control littermates treated with tamoxifen (−5 to 0) and injected with LV-GFPstop or LV-BDNFprostop the last day of tamoxifen treatment (0 dptm) were subjected to ORT (14 dptm). Discrimination index is plotted against time interval between sample phase and test phases. **p < 0.01 (post hoc Holm–Sidak) (n = 11 mice for p75-flox/LV-GFPstop; n = 10 mice for p75-flox/LV-BDNFprostop; n = 5 mice for control littermates). c Schematic diagram depicting the experimental paradigm as in (b). The dot plot shows mean exploration time of the familiar object and the novel object in the sample phase (n = 11 mice for p75-flox/LV-GFPstop; n = 10 mice for p75-flox/LV-BDNFprostop; n = 5 mice for control littermates). Data are presented as mean ± SEM.
