Fig. 3: XL-MS analysis provides insight into the overall topology of the BRD4 dimer. | Communications Biology

Fig. 3: XL-MS analysis provides insight into the overall topology of the BRD4 dimer.

From: Phosphorylation-dependent BRD4 dimerization and implications for therapeutic inhibition of BET family proteins

Fig. 3

Graphical representation of the cross-link (XL)-MS analysis. Cross-links found only in the CK2 phosphorylated sample (green) or only in the unphosphorylated sample (purple) are represented as inter-molecular cross-links or intra-molecular cross-links, respectively. The regions showing a reduced deuterium uptake upon phosphorylation in the HDX-MS experiment are highlighted with pale yellow: aa 65–71, 184–190, 362–386, 506–527, 621–644, 657–675.

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