Fig. 8: Single nucleotide polymorphism rs144921258 associates with primary cause of death from gastrointestinal hemorrhage within the UK Biobank cohort.
From: CD36 maintains the gastric mucosa and associates with gastric disease
a Genomic coordinates along chromosome 7q (x-axis), with negative logarithm of p-values (y-axis) for SNP association with gastrointestinal hemorrhage p = 7.9-17. Location of rs144921258 in CD36 on chr7q is indicated by a diamond. The schematic of the CD36 gene below the plot also depicts the position of GNAT3, which overlaps a distal promoter of CD36. b Position of rs144921258 relative to the abundant proximal CD36 promoter 1B, (shown with its long 3’ untranslated region) and to SNPs previously associated with methylation at CpG sites with impact on CD36 expression and lipid handling. Red CpGs: SNP-associated methylation sites that impact CD36 expression. Purple SNPs: SNPs associated with both lipid levels and low CD36 expression. See also Table 1 and Results.
