Fig. 9: CD36 regulates stomach function and tissue renewal postinjury.
From: CD36 maintains the gastric mucosa and associates with gastric disease
CD36 is abundant in corpus endothelial cells (EC) and expressed in parietal cells (PC). It is not detected in chief cells (CC), but its deficiency through vagal input and likely muscarinic receptor 1, suppresses CC release of leptin and gastric intrinsic factor (GIF), respectively. GIF is necessary for ileal vitamin B12 absorption. CD36 deletion reduces endothelial delivery of fatty acids to the corpus, tissue energy stores and mitochondrial FA oxidation, critical for stem cell functionality. Impaired renewal of the CD36-/- gastric epithelium reflects defective PC progenitor differentiation to PCs and not progenitor proliferation or dysfunction of mature PCs. Low gastric leptin secretion could further impair tissue healing. The reduced tissue ability for adequate repair would contribute to the etiology of gastric disease, as supported by data from two biomedical databases (see Fig. 8 and Table 1).
