Fig. 3: Trajectories across t-types on the latent space after nonlinear manifold alignment along with continuous electrophysiology changes. | Communications Biology

Fig. 3: Trajectories across t-types on the latent space after nonlinear manifold alignment along with continuous electrophysiology changes.

From: Manifold learning analysis suggests strategies to align single-cell multimodal data of neuronal electrophysiology and transcriptomics

Fig. 3: Trajectories across t-types on the latent space after nonlinear manifold alignment along with continuous electrophysiology changes.

a Scatterplots show trajectories across t-types on the latent space (3D used here) after nonlinear manifold alignment of the cells in the visual cortex (left) and motor cortex (right). Cells in shared t-types between two regions are highlighted with the same color for comparison. Red: Vip type; Blue: Sst type; Purple: Sncg type; Orange: Pvalb type; Yellow: Lamp5 type; Gray: other t-types not shared (e.g., Excitatory neurons in the visual cortex). b Scatterplots show trajectories for Sst sub t-types on the latent space (3D used here) after nonlinear manifold alignment of the cells in the visual cortex (left) and motor cortex (right). c Scatterplots show continuous changes of select electrophysiological features in t-types and Sst sub-t-types in the visual cortex (left) and motor cortex (right). The “peak t ramp” is the time taken from membrane potential to AP peak for ramp stimulus.

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