Fig. 1: Body-wide biodistribution and slow elimination of a SP in mice.
From: Spike protein multiorgan tropism suppressed by antibodies targeting SARS-CoV-2
a External in vivo dynamic SP-NIRF image of a mouse after its intravenous injection (after a few minutes). Regions of interest (ROIs) selected for the analysis. b Representative SP-NIRF intensity-time profile for each ROI over 60 min. c Standardization of data by dividing intensities at each time point by the peak intensity (IT/IP ratio). d Peak intensity for the ROIs. e Area under the curve (AUC) for the ROIs. Values are mean ± SEM, N = 4 young male mice (2–3 months old). f Plasma intensities at 2 and at 60 min, and CSF levels at 60 min. Values are mean ± SEM, N = 3 young male mice. AU (arbitrary units).
