Fig. 3: Neuronal activity levels are largely stable over time.
From: Long-term dynamics of aberrant neuronal activity in awake Alzheimer’s disease transgenic mice
a Representative FOVs across all 3 time points from a WT and APPPS1 mouse, superimposed by the ROI (region of interest) selection mask (color codes for neuronal activity (transients per minute); filled cells were not included in the analysis; dashed lines: amyloid plaques). b Change in neuronal activity (week 0–2: p = 0.08, week 0–4: p = 0.03, KS test, WT n = 471 neurons (5 mice), APPPS1 n = 1514 neurons (9 mice)). c Similarity of neuronal activity within a given field of view (week 0–2: F3,74 = 105.7, p < 10−4, one way ANOVA, WT vs WT shuffled p < 10−4, WT vs APPPS1 p = 0.9, APPPS1 vs APPPS1 shuffled p < 10−4, Bonferroni’s post-hoc test; week 0–4: F3,74 = 78.51, p < 10−4, one way ANOVA, WT vs WT shuffled p < 10−4, WT vs APPPS1 p = 0.9, APPPS1 vs APPPS1 shuffled p < 10−4, Bonferroni’s post-hoc test). Data are mean ± SEM. *p < 0.05, ***p < 0.001.
