Table 1 Clinico-pathological variables in relation to the radiomic clusters based on the manually segmented tumors (n = 138).

From: A radiogenomics application for prognostic profiling of endometrial cancer

Variable

Description

Radiomic clusters, n (%)

p valuea

Cluster 1 (n = 70)

Cluster 2a/b (n = 68)

Age

<66

38 (57.6)

28 (42.4)

0.130

≥66

32 (44.4)

40 (55.6)

Histologic type

Endometrioid

63 (56.3)

49 (43.8)

0.014

Non-endometrioid

7 (28.0)

18 (72.0)

Histologic gradeb

Grade 1–2

55 (63.2)

32 (36.8)

0.001

Grade 3

5 (22.7)

17 (77.3)

FIGO stage

I–II

66 (55.9)

52 (44.1)

0.006

III–IV

4 (21.1)

15 (78.9)

Myometrial infiltration

<50%

56 (75.7)

18 (24.3)

<0.001

≥50%

14 (22.2)

49 (77.8)

Lymph node metastasis

No

40 (48.8)

42 (51.2)

0.020

Yes

2 (14.3)

12 (85.7)

Ploidy

Diploid

24 (43.6)

31 (56.4)

0.424

Aneuploidy

6 (31.6)

13 (68.4)

ER protein expressionc

High expression

27 (52.9)

24 (47.1)

0.059

Low expression

8 (29.6)

19 (70.4)

PR protein expressionc

Positive

31 (52.5)

28 (47.5)

0.064

Negative

5 (26.3)

14 (73.7)

AR protein expressionc

Positive

16 (51.6)

15 (48.4)

0.451

Negative

12 (41.4)

17 (58.6)

  1. Missing data (numbers): Histologic type (1), Histologic grade (3), FIGO stage (1), Myometrial infiltration (1).
  2. Not assessed (numbers): Lymph node metastasis (42), Ploidy (64), ER (60), PR (60), and AR (78).
  3. Including one inoperable patient.
  4. a Calculated with Chi-Square test or Fischer’s exact test, as appropriate.
  5. b Endometrioid type only.
  6. c Protein levels by immunohistochemistry (IHC).
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