Table 3 Clinico-pathological variables in relation to the 11-gene signature score in the L1000 dataset (n = 392).
From: A radiogenomics application for prognostic profiling of endometrial cancer
Variable | Description | Signature score, n (%) | p valuea | |
|---|---|---|---|---|
Low (n = 245) | High (n = 147) | |||
Age | <66 | 143 (70.1) | 61 (29.9) | 0.002 |
≥66 | 102 (54.3) | 86 (45.7) | ||
Histologic type | Endometrioid | 238 (75.6) | 77 (24.4) | <0.001 |
Non-endometrioid | 7 (9.1) | 70 (90.9) | ||
Histologic gradeb | Grade 1–2 | 212 (83.5) | 42 (16.5) | <0.001 |
Grade 3 | 23 (39.7) | 35 (60.3) | ||
FIGO stage | I–II | 223 (65.6) | 117 (34.4) | 0.002 |
III–IV | 22 (42.3) | 30 (57.7) | ||
Myometrial infiltration | <50% | 165 (71.1) | 67 (28.9) | <0.001 |
≥50% | 80 (50.0) | 80 (50.0) | ||
Lymph node metastasis | No | 179 (62.2) | 109 (37.8) | 0.006 |
Yes | 13 (37.1) | 22 (62.9) | ||
Ploidy | Diploid | 148 (69.2) | 66 (30.8) | <0.001 |
Aneuploidy | 20 (30.3) | 46 (69.7) | ||
ER protein expressionc | High expression | 184 (74.5) | 63 (25.5) | <0.001 |
Low expression | 29 (30.2) | 67 (69.8) | ||
PR protein expressionc | Positive | 199 (77.4) | 58 (22.6) | <0.001 |
Negative | 17 (19.3) | 71 (80.7) | ||
AR protein expressionc | Positive | 150 (73.9) | 53 (26.1) | <0.001 |
Negative | 50 (43.9) | 64 (56.1) | ||
