Fig. 2: Comparison of IO and OO conformations of ABCD1.
From: Structures of the human peroxisomal fatty acid transporter ABCD1 in a lipid environment
a EM density map (0.04 contour) of human ABCD1 IO (cytoplasm facing) conformation colored yellow and gray for two monomers with similarly colored ribbon representing the protein backbone at right. b All Cα-atom overlay of IO and OO structures of human ABCD1 (gold and blue ribbons, respectively) with TMs numbered and external helix (EH) shown for IO conformation, with far viewing plane clipped to 10 Å. c Superposition of individual TM pairs from IO and OO structures with TM4 disrupting P263 & G266. d Comparison of NBDs of IO and OO structures aligned using NBD1 as reference from the lumenal viewpoint. Arrows depict inter coupling helix 2 (CH2) distances between Y296 Cα atoms.
