Fig. 2: Weighted gene co-expression network analysis (WGCNA).

The gene co-expression network is displayed with genes as nodes and edges representing the co-expression relationships between genes. Nine modules were detected within which gene expression was especially strongly correlated (see Supplementary Fig. 2 for more details.) Shown are the seven largest modules, represented by colors. For each module, information is supplied on the caste or queen stage with which module expression is significantly correlated; upward arrow indicates a significant increase, downward arrow a significant decrease, in expression. The top three enriched GO terms associated with the gene members of each module are displayed (for full lists of significant GO terms, see Supplementary Data 1). This network was created with Cytoscape (version 3.8.0; Shannon et al.77) on a reduced representation of the WGCN containing the top connected genes (see “Methods” for more details).