Fig. 2: AUC for combinations of age, sex, and individual risk factors and the GRIT scores in UK Biobank. | Communications Biology

Fig. 2: AUC for combinations of age, sex, and individual risk factors and the GRIT scores in UK Biobank.

From: Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes

Fig. 2: AUC for combinations of age, sex, and individual risk factors and the GRIT scores in UK Biobank.

Panel a shows results for CHD (N = 242,687 participants) and panel b for T2D (N = 121,113). The AUC was first calculated for age and sex and additionally for each individual risk factor integrated with age and sex. Lastly, the AUC was calculated for the GRIT scores and the GRIT scores without PRSs. Points indicate AUC estimates and error bars represent the 95% CIs for each factor with incident disease as endpoint. BMI body mass index, LDL low-density lipoprotein, HDL high-density lipoprotein, TG triglycerides, CVD cardiovascular disease.

Back to article page