Table 1 Baseline participant characteristics.
Coronary heart disease | Derivation, N = 61,878 (FinnGen) | Validation, N = 242,687 (UK Biobank) | ||||||
|---|---|---|---|---|---|---|---|---|
Men, N = 33,774 | Women, N = 28,104 | Men, N = 105,439 | Women, N = 137,248 | |||||
Cases N = 2938 | Non-cases N = 30,836 | Cases N = 598 | Non-cases N = 27,506 | Cases N = 3272 | Non-cases N = 102,167 | Cases N = 1197 | Non-cases N = 136,051 | |
Age, mean ± SD | 60.2 ± 8.1 | 52.7 ± 10.7 | 61.4 ± 8.1 | 51.1 ± 10.7 | 59.9 ± 6.9 | 56.1 ± 8.2 | 61.2 ± 6.4 | 56.4 ± 7.9 |
Current smoker, n (%) | 1945 (66.2) | 13,978 (45.3) | 148 (24.7) | 5339 (19.4) | 551 (16.8) | 11,816 (11.6) | 216 (18.0) | 11,338 (8.3) |
Any diabetesa, n (%) | 233 (7.9) | 1167 (3.8) | 96 (16.0) | 1100 (4.0) | 119 (3.6) | 1804 (1.8) | 30 (2.5) | 1293 (1.0) |
Use of antihypertensive medications, n (%) | 368 (12.5) | 2933 (9.5) | 196 (32.8) | 3765 (13.7) | 617 (18.9) | 12,021 (11.8) | 261 (21.8) | 14,582 (10.7) |
BMI, kg/m2, mean ± SD | 27.6 ± 4.1 | 27.0 ± 4.1 | 28.4 ± 5.5 | 26.6 ± 5.2 | 28.1 ± 4.0 | 27.4 ± 4.0 | 27.6 ± 4.9 | 26.7 ± 4.9 |
Family history of CHD, n (%) | n/a | n/a | n/a | n/a | 1599 (48.9) | 37,375 (36.6) | 672 (56.1) | 59,195 (43.5) |
Type 2 diabetes | Derivation, N = 69,159 (FinnGen) | Validation, N = 121,113 (UK Biobank) | ||||||
|---|---|---|---|---|---|---|---|---|
Men, N = 38,861 | Women, N = 30,298 | Men, N = 55,898 | Women, N = 65,215 | |||||
Cases N = 3234 | Non-cases N = 35,627 | Cases N = 1658 | Non-cases N = 28,640 | Cases N = 1532 | Non-cases N = 54,366 | Cases N = 1012 | Non-cases N = 64,203 | |
Age, mean ± SD | 58.9 ± 8.5 | 54.2 ± 10.9 | 57.6 ± 9.7 | 52.1 ± 11.1 | 60.2 ± 7.0 | 57.2 ± 8.1 | 59.9 ± 7.1 | 56.9 ± 7.9 |
Current smoker, n (%) | 1612 (49.8) | 16,656 (46.8) | 374 (22.6) | 5501 (19.2) | 218 (14.2) | 6076 (11.2) | 136 (13.4) | 5406 (8.4) |
Use of antihypertensive medications, n (%) | 948 (29.0) | 4644 (13.0) | 646 (39.0) | 4727 (16.5) | 669 (43.7) | 11,365 (20.9) | 366 (36.2) | 9254 (14.4) |
Statin therapy, n (%) | 458 (14.2) | 2,274 (6.4) | 280 (16.9) | 1,902 (6.6) | 551 (36.0) | 9645 (17.7) | 257 (25.4) | 5795 (9.0) |
BMI, kg/m2, mean ± SD | 30.3 ± 4.7 | 26.7 ± 3.8 | 31.6 ± 6.0 | 26.4 ± 4.9 | 31.1 ± 4.7 | 27.5 ± 3.9 | 31.8 ± 6.0 | 26.7 ± 4.8 |
Prevalent CVD, n (%) | 744 (23.0) | 3,896 (11.0) | 217 (13.1) | 1494 (5.2) | 350 (22.8) | 4811 (8.9) | 124 (12.3) | 2430 (3.8) |
Gestational diabetes, n (%) | n/a | n/a | 64 (3.9) | 473 (1.7) | n/a | n/a | 22 (2.2) | 220 (0.3) |
Family history of T2D, n (%) | n/a | n/a | n/a | n/a | 452 (29.5) | 9756 (17.9) | 403 (39.8) | 13,268 (20.7) |
