Fig. 3: Abnormal mitochondria in pre-AML platelets. | Communications Biology

Fig. 3: Abnormal mitochondria in pre-AML platelets.

From: Using Cryo-ET to distinguish platelets during pre-acute myeloid leukemia from steady state hematopoiesis

Fig. 3: Abnormal mitochondria in pre-AML platelets.

a Roughly a quarter of mitochondria in pre-AML platelets were abnormal with reduced cristae and matrix (scale bar 100 nm). b 18.1% of the pre-AML platelets had one abnormal mitochondrion and 5.5% have more than one abnormal mitochondrion. c The statistical analysis of mitochondrial circularity (P < 0.0001) d ATP measurement assay for mitochondria in control and pre-AML platelets. e Gene set enrichment analysis (GSEA) on the platelets from pre-AML and control mice. “HYPOXIA” and “INFLAMMATORY_RESPONSE” were up-regulated and “MTORC1_SIGNALING” and “OXIDATIVE_PHOSPHORYLATION” were down-regulated in pre-AML platelets, compared with control platelets. Data in (c) and (d) are presented as mean ± s.e.m. Student’s t test was used for statistical analyses. *P  ≤  0.05.

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