Fig. 1: LiCl suppresses neuronal activation of NLRP3 inflammasome and the pyroptosis related GSDMD induced by MCAO.
From: The neuroprotective mechanism of lithium after ischaemic stroke
a–c Green immunofluorescence of NLRP3 (a), caspase-1 (b) and GSDMD (c) co-stained with neuronal marker NeuN (red) and nucleus marker DAPI (blue) in the injured ipsilateral cortex. Scale bar 50 μm. d Immunofluorescence intensities of NLRP3, caspase-1 and GSDMD in cortical neurones normalised to sham-NS group. The immunofluorescence intensities were normalised to control group and plotted as mean ± SD. N = 6 per group. One-way ANOVA for comparisons including more than two groups; unpaired two-tailed t-test for two group comparisons. *p < 0.05, **p < 0.01, ***p < 0.001.
