Table 4 Effects of in silico αCOPI-WD40 mutagenesis on spike hepta-peptide binding.

From: An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking

αCOPI-WD40 mutation

Change in interaction energy (∆∆G, Rosetta Units)

Predicted binding change with αCOPI-WD40

Lys15 → Ala

0.8

Weakened

His31 → Ala

0.8

Weakened

Arg57 → Ala

1.2

Weakened

Asp115 → Ala

0.9

Weakened

Tyr139 → Ala

1.1

Weakened

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