Fig. 4: Itk−/− T cells receive strong signals in vivo during the development of SR-induced hypersensitivity pneumonitis. | Communications Biology

Fig. 4: Itk−/− T cells receive strong signals in vivo during the development of SR-induced hypersensitivity pneumonitis.

From: ITK independent development of Th17 responses during hypersensitivity pneumonitis driven lung inflammation

Fig. 4

a CD4+ T cells from non-exposed WT (filled circles) or Itk−/− (open circles) Nurr77-GFP mice were analyzed for expression of Nurr77-GFP and MFI plotted (n = 4 for WT group; n = 6 for Itk−/− group, *p = 1.1e−7). b WT (filled circles) or Itk−/− (open circles) Nurr77-GFP mice were exposed to SR as in Fig. 1, and lung CD4+ T cells were analyzed for expression of Nurr77-GFP and MFI plotted (n = 3/group, *p = 0.0006). c Expression of Nr4a1 (gene for Nurr77) determined from RNA-sequencing (FKPM) (data from cells used for RNA-sequencing analysis depicted in Fig. 5, WT (filled circles) or Itk−/− (open circles), n = 3/group, *p = 4.8e−5).

Back to article page