Fig. 3: SOD1G93A motor neurons exhibit altered synaptic functions concomitant with increased cell death-associated pathways at peri-symptomatic onset stage of disease.
From: Neuronal–glial communication perturbations in murine SOD1G93A spinal cord
a Volcano plot of differential expression between genotypes in motor neurons. Genes with FDR < 0.1 are colored red (up-regulated) or blue (down-regulated). b Motor neuron Reactome gene sets that are significantly differentially expressed between genotypes in both ROAST and CAMERA displayed as a network. c Motor neuron KEGG gene sets that are significantly differentially expressed between genotypes in both ROAST and CAMERA displayed as a network. For b, c: Internode line thickness reflects number of shared genes. Node size represents number of genes in the set. Red and blue nodes denote up-regulation and down-regulation, respectively. d Density plot of RCOR1 regulon activity scores for motor neurons. N = 3 independent mice per genotype per sex.
