Fig. 4: PDGFB and PREX1 correlates with Notch ligand switching and negative sGC regulation in human carotid artery atherosclerotic plaques.
From: PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle
a mRNA expression of PDGFB, GUCY1A3, GUCY1B3, JAG1, and DLL4 in early and late stage atherosclerotic lesions. b Correlation of PDGFB with GUCY1A3, GUCY1B3, JAG1, and DLL4 expression in late stage atheromas. c mRNA expression of Notch target genes BCL2, HEYL, HEY2, and TAGLN in early and late stage atherosclerotic lesions. d Correlation of PDGFB with BCL2, HEYL, HEY2, and TAGLN expression in late stage atheromas. e Correlation of PREX1 with GUCY1A3, GUCY1B3, JAG1, DLL4, BCL2, HEYL, HEY2, and TAGLN expression in late stage atheromas. Sample data obtained from GEO dataset GSE43292. Correlation analysis was performed with Pearson’s correlation test.
