Fig. 7: Hypothesis for evolution of luminal hyperplastic lesions from CD200low MEP progenitors. | Communications Biology

Fig. 7: Hypothesis for evolution of luminal hyperplastic lesions from CD200low MEP progenitors.

From: Myoepithelial progenitors as founder cells of hyperplastic human breast lesions upon PIK3CA transformation

Fig. 7

Schematic drawing shows distribution of CD200low MEP cells (blue) in alveoli and CD200high MEP cells (red) in terminal ducts and ducts. CD200low MEP progenitors are multipotent since they can generate K14+/K19− MEP cells (green), K14+/K19+ luminal progenitor cells (yellow) as well as K14−/K19+ luminal cells of alveoli and ducts (orange). Upon oncogenic activation as shown here by overexpression of PIK3CAH1047R, CD200low MEP progenitors can give rise to biphasic lesions with luminal hyperplasia.

Back to article page