Fig. 1: Antiviral effects of SFN against HCoV-OC43. | Communications Biology

Fig. 1: Antiviral effects of SFN against HCoV-OC43.

From: Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice

Fig. 1: Antiviral effects of SFN against HCoV-OC43.The alternative text for this image may have been generated using AI.

Median effect plots and dose-effect curves calculated for a Vero C1008 cells infected with HCoV-OC43 after a 1–2 h incubation with increasing concentrations of SFN; b MRC-5 cells infected with HCoV-OC43 after a 1–2 h incubation with increasing concentrations of SFN; c Vero C1008 cells infected with HCoV-OC43 over 24 h, after which they were incubated with SFN; d Vero C1008 cells incubated with SFN for 24 h, after which the drug was removed, and the cells were infected with HCoV-OC43; e Vero C1008 cells infected with HCoV-OC43 after a 1–2 h incubation with increasing concentrations of remdesivir. f Normalized isobologram showing combination index (CI) for combinations of various doses. Antiviral data is displayed in red; anti-host cell activity (cytotoxicity) is displayed in blue. Synergism (CI < 1); additive effect (CI = 1); antagonism (CI > 1); SFN, Sulforaphane; RDV, remdesivir. Dotted lines represent 95% confidence interval. Experiments were performed a minimum of 2 times (range = 2–7), 3–6 replicates within each experiment, except experiment shown in (d), which was performed once.

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