Fig. 4: Recurrence and density of SVs in 1 Mb genomic bins.

a Scatter plot showing recurrence, the number of patients with an SV break in each 1 Mb bin (y-axis) and density, the average number of SV breaks in the bin over all tumours (x-axis). Bins are labelled with genes or fragile sites that they overlap: black, fragile sites; purple, intervals of amplification and deletion; red, putative genes under selection. b Manhattan plot showing 1MB bins containing putative drivers (red) and fragile sites (black) and genes coloured by methods discovered: Glodzik model adjusting for genomic context (Black), Focal (F, blue) and both methods (brown: FG). c Oncoplot showing candidate driver genes identified using focal and Glodzik methods and annotated if each gene was found in Frankell et al. (2019). Horizontal bar plots show total number of simple (light orange) and complex (dark orange) SVs found in the given gene; proportions of SVs classified as simple that are of the various SV types; and similarly for SVs classified as complex. Each oncoplot cell shows if each patient has a simple or complex SV and the combination of SV types.