Fig. 4: Multivariable Mendelian randomization results of childhood body size direct estimates accounted for selected mediators.
From: Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization
The plot shows the odds of breast cancer per SD change in the direct effect (red) of childhood body size accounted for mediators. The total effect (blue) (OR: 0.66 [0.57: 0.76]) and direct effect (i.e., accounted for adult body size, OR: 0.62 [0.51: 0.75]) estimates of childhood body size on breast cancer risk were re-calculated (Supplementary Data 6) from the original study [15] (using the thresholds defined in the Methods to match other MR analysis in this study), included here for comparison. The vertical blue line shows the value of the total childhood body size effect point estimate (0.66) relative to the direct estimates. Bars indicate 95% confidence intervals around the point estimates from IVW-MVMR. The estimated values and the numbers of genetic variants included in the analyses are given in Supplementary Data 5. The details about the datasets are given in Table 1.
