Fig. 5: Mediation analysis results: indirect effect of childhood body size on breast cancer via a mediator.
From: Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization
The indirect effect was estimated as the product of coefficients of the total effect of exposure on the mediator (step 1 of two-step MR) and the direct effect of a mediator on the outcome (MVMR), i.e., Product method, and the 95% CIs were calculated based on SE estimated using Delta method. The presented data is available in Supplementary Data 18. The details about the datasets are provided in Table 1.
