Fig. 2: Manhattan plot of association P values for the European ancestry specific meta-analysis of GWAS of circulating total-tau levels.

The –log10(P)-value for each single nucleotide variant on the y axis is plotted against the build 37 genomic position on the x axis (chromosomal coordinate). The dashed horizontal red line indicates the genome-wide significance threshold of P = 5 × 10−8 and the dashed horizontal black line indicates the threshold of P = 5 × 10−7. The y axis was truncated for ease of interpretation.