Fig. 2: Contribution of previously identified lipid GWAS variants to lpidomics variance.
From: An Amish founder population reveals rare-population genetic determinants of the human lipidome
Heritability estimates using adjusted kinship separately (Adjusted for 4 Amish-enriched lipid variants (APOB_rs574290415, APOC3_rs7635320314, B4GALT1_rs55156468321, TIMD4_rs89895600320) and then jointly with a SNP GRM for each traditional lipid. Analysis restricted to 194 lipid species with baseline significant heritability (Kinship + 4 V heritability p-value < 0.01). The upper, center, and lower line of the boxplot indicates third quartile (Q3), median, first quartile (Q1), respectively. The upper and lower whisker of the boxplot indicates Q3 + 1.5 * interquartile range (IQR) and Q1 − 1.5 * IQR. Outliers are suppressed from the plot for readability. ACT Acylcarnitine, CE Cholesteryl ester, Cer Ceramide, DAG Diglycerides, FA Fatty acids, GlcCer Glycosphingolipids, LPC Lysophosphatidylcholines, LPE Lysophosphatidylethanolamines, PC Phosphatidylcholines, PE Phosphatidylethanolamine, PI Phosphatidylinositol, SM Sphingomyelin, TAG Triglycerides, ST Sterols.
