Fig. 3: The interaction effects of MAOA-uVNTR and 5-HTT gene variants on the eMMN. | Communications Biology

Fig. 3: The interaction effects of MAOA-uVNTR and 5-HTT gene variants on the eMMN.

From: Interaction effects of the 5-HTT and MAOA-uVNTR gene variants on pre-attentive EEG activity in response to threatening voices

Fig. 3

a Fearful MMN. The interaction effect of MAOA-uVNTR × 5-HTT was significant in male (n = 62) (F1, 58 = 6.26, P = 0.015, ηp2 = 0.097) but not in female participants (n = 78) (F1, 74 = 0.399, P = 0.529, ηp2 = 0.005). In men, MOAO exerted its effect only in ones who do not possess a 5-HTT genotype of SS (n = 31) [T(29) = 2.33, P = .027]. Men with MAOA-low (n = 11) (3.74 ± 0.97 μV) showed significant larger fearful MMN than men with MAOA-high (n = 20) (1.84 ± 0.3 μV) in the 5-HTT-LL/LS group, whereas they are parallel in the 5-HTT-SS group [MAOA-low (n = 13): 1.66 ± 0.49 μV; MAOA-high (n = 18): 2.88 ± 0.72 μV; T(29) = −1.3, P = 0.2]. b Angry MMN. The interaction effect of MAOA-uVNTR × 5-HTT was not significant in both male and female participants (male: F1, 58 = 3.247, P = 0.077, ηp2 = 0.053; female: F1, 74 = 0.288, P = 0.593, ηp2 = 0.004). Whisker boundaries were set as box edge ± 1.5 Inter-Quartile Range (IQR). Source data are presented in Supplementary Data 2.

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