Fig. 6: ROCK2 inhibition attenuates diabetic podocytopathy through targeting PPARα.
From: ROCK2-induced metabolic rewiring in diabetic podocytopathy
a A schematic summary of key observations. In diabetic kidneys, podocyte ROCK2 is upregulated with proteinuria. Podocyte-specific ROCK2 deletion prevents the loss of podocytes by recovering PPARα signaling.
