Table 1 Demographic characterization of the MESA participants across race/ethnic groups.

From: Lymphocyte activation gene-3-associated protein networks are associated with HDL-cholesterol and mortality in the Trans-omics for Precision Medicine program

Participant characteristics

Pooled

White

Chinese

African-American

Hispanic

No. subjects

3867

1573

467

876

887

Women

1960 (50.7)

782 (49.7)

231 (49.5)

456 (52.1)

447 (50.4)

Age, years

61 (53,69)

61 (53,69)

61 (52,69)

61 (53,68)

60 (52,68)

Current smoke (yes/no)

462 (12.0)

172 (10.9)

28 (6.0)

151 (17.2)

106 (12.0)

Lipid medication (yes/no)

620 (16.0)

274 (17.4)

73 (15.6)

129 (14.7)

126 (14.2)

BMI, kg/m2

27.5 [24.5, 30.9]

27.2 [24.3, 30.3]

23.9 [22.0, 26.1]

29.2 [26.3, 33.2]

28.6 [26.0, 31.7]

fasting glucose (mg/dl)

89 [82,98]

87 [81,94]

91 [85, 101]

91 [83, 101]

92 [84, 103]

Systolic blood pressure (SBP) (mmHg)

122 [111, 138]

120 [110, 135]

120 [108, 137]

129 [116, 142]

122 [111, 139]

Diastolic blood pressure (DBP) (mmHg)

72 [65,79]

71 [64,78]

72 [66,78]

74 [68,81]

72 [65,79]

HDL-C, mg/dl

48 (40,59) (n = 3865)

50 (41,61) (n = 1572)

48 (40,55) (n = 467)

50 (41,60) (n = 875)

45 (39,54) (n = 887)

LDL-C, mg/dl

116 [96, 136] (n = 3819)

115 [96, 136] (n = 1555)

113 [96, 131] (n = 467)

117 [96, 136] (n = 872)

119 [99, 138] (n = 869)

Triglycerides, mg/dl

113 [78, 163] (n = 3867)

113 [77, 165] (n = 1573)

128 [87, 170] (n = 467)

90 [66, 121] (n = 876)

135 [97, 191] (n = 887)

LAG3 protein levels (Ex 1), RFU

6420.8 [5422.5, 7773.1] (n = 833)

6401.1 [5360.9, 7802.6] (n = 352)

7709.4 [6432.2, 9100.4] (n = 62)

6203.7 [5194.9, 7106.0] (n = 154)

6388.1 [5512.6, 7533.3] (n = 248)

LAG3 protein levels (pg/ml) (Ex 2)

496 [231, 1340] (n = 3612)

447 [206, 1144] (n = 1526)

674 [322, 1603] (n = 462)

536 [202, 2461] (n = 881)

505 [261, 1168] (n = 847)

Presence of calcium indicator (yes/no)

1806 (47.3) (n = 3819)

819 (52.7) (n = 1555)

221 (47.3) (n = 467)

358 (41.1) (n = 872)

375 (43.2) (n = 869)

Agatston calcium score (among those with CAC > 0)

77.9 [18.9, 274.2] (n = 1806)

99.7 [20.2, 328.8] (n = 819)

67.1 [25.5, 221.5] (n = 221)

53.1 [17.2, 232.5] (n = 358)

73.8 [18.9, 248.0] (n = 375)

Common carotid intimal-medical thickness (mm)

0.84 [0.73, 0.96] (n = 3804)

0.83 [0.72, 0.96] (n = 1549)

0.80 [0.70, 0.91] (n = 467)

0.88 [0.76, 1.00] (n = 866)

0.82 [0.73, 0.93] (n = 866)

Internal carotid intimal-medical thickness (mm)

0.84 [0.68, 1.20] (n = 3746)

0.87 [0.71, 1.31] (n = 1532)

0.73 [0.60, 0.88] (n = 462)

0.85 [0.67, 1.28] (n = 850)

0.82 [0.66, 1.15] (n = 847)

Ankle-brachial index (ABI)

1.13 [1.06, 1.19] (n = 3788)

1.14 [1.07, 1.20] (n = 1540)

1.12 [1.07, 1.18] (n = 466)

1.10 [1.03, 1.16] (n = 863)

1.14 [1.08, 1.20] (n = 865)

Stroke (yes/no)

179 (0.047) (n = 3816)

72 (0.046) (n = 1553)

17 (0.036) (n = 467)

35 (0.040) (n = 872)

54 (0.062) (n = 868)

Myocardial infarction (MI) (yes/no)

188 (0.049) (n = 3816)

84 (0.054) (n = 1553)

17 (0.036) (n = 467)

34 (0.039) (n = 872)

51 (0.059) (n = 868)

Follow-up time (days)

5539 [5317, 5745]

5610 [5357, 5791]

5538 [5311, 5745]

5456 [5280, 5658]

5509 [5289, 5738]

  1. Data are presented as n (%) for binary measures or median [Interquartile range (IQR)] for continuous measure. N = number of participants in each variable. Descriptive statistics for covariates and phenotypes are reported based on the baseline examination (Exam 1), except where noted otherwise. Descriptive statistics for events are presented based on MESA adjudication through the year 2016. Summary statistics are reported based on the subset of samples included in genetic analyses. SOMAscan proteomics, RFU = relative fluorescent units.
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