Fig. 8: Presynaptic and postsynaptic molecular markers of synaptic physiology. | Communications Biology

Fig. 8: Presynaptic and postsynaptic molecular markers of synaptic physiology.

From: Normalized unitary synaptic signaling of the hippocampus and entorhinal cortex predicted by deep learning of experimental recordings

Fig. 8

a Comparison of synaptic signals between presynaptic neuron types expressing (+) or not expressing (−) parvalbumin (PV). The consensus trace was simulated with synaptic parameters averaged across all potential connections in each group. The sample traces are from the CA1 Basket PV+ to CA1 Pyramidal connection (+), and from CA1 Basket CCK+ to CA1 Pyramidal (−). b Symmetric percentage differences (SPD) in synaptic parameters between potential connections grouped by the expression or absence of specific presynaptic or postsynaptic molecular markers (with corresponding samples sizes). Positive values signify that the measurement is larger in the (+) than in the (−) group, and vice versa. Error bars indicate confidence intervals and asterisks denote statistical significance by unpaired Wilcoxon test at the p < 0.05 level after False Discovery Rate correction63 for multiple testing. The dataset underlying this analysis and the listing of all 36 p-values are available in Supplementary Data 1.

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